of affected organs (TACE)
TACE is a combination of transarterial embolisation and regional chemotherapy with the major advantage that chemotherapeutic drugs remain in the tumor tissue for a longer period at a higher concentration, while the embolotherapy interrupts the arterial blood flow to the tumor and inhibits washout of the injected chemotherapeutic drugs. TACE has been widely used in liver cancer, where selective arterial obstruction induces ischemic tumor necrosis while minimizing damage to the liver tissue, but can also be administered to other cancer-affected organs.
The use of combination therapy results in lower systemic drug levels and therefore less toxicity. Thus, the combination of embolotherapy and regional chemotherapy offers a promising treatment option with synergistic and anti-tumor effects.
High intensity focused ultrasound
High intensity focused ultrasound (HIFU) is a non-invasive technology used to treat tumor masses by high intensity ultrasound that induces coagulative thermal necrosis due to the absorption of ultrasound energy in tissue. HIFU is being used to treat a variety of solid malignant tumors, including tumors of the pancreas, liver, prostate, breast, uterus, and certain sarcomas. Its main advantage are non-invasion, non-ionization, and fewer complications after treatment.