Haematological cancerous diseases of the body, also known as blood cancer, is a malignancy of the blood cells and have its primary in the bone marrow. A leukemia is subdivided into acute and chronic forms, and according to which kind of blood cell is affected. Furthermore, lymphomas belong to haematological cancerous diseases.
The most common signs and symptoms of a haematological disease include easy bruising, bleedings and petechiae, night sweats, as well as pale skin, enlarged liver or spleen, fever, and lymph node swellings. Haematological diseases are usually diagnosed on the basis of blood counts, and bone marrow examinations.
Depending on the character and form of the disease, treatment may involve some combination of chemotherapy, radiotherapy, autologous- or allogenic stem cell transplant, or immunotherapy like for instance chimeric monoclonal antibodies. The treatment for acute haematological diseases is very intense, since acute leukemias are known to affect inner organs, which can lead to a treatment break, or a change of treatment protocol, e.g. due to a deterioration of the kidney function. The treatment of chronic leukemias differs. Since a large group of patients with i.e. a CLL have a low-grade disease, they do not benefit from treatment. For this type, a treatment is considered at an advanced stage, and once the disease is accompanied by dominant symptoms. In contrast, CML is often treated with a genetic targeted therapy as i.e. tyrosine kinase inhibitors, that are taken orally.
In case of a suspicion of a haematological disease, a bone marrow puncture, or lymph node biopsy takes place. This material is used for a histopathological analysis, to determine the exact (cell) type. There are many different types, and each of them presents unique genetic characteristics.
What most patients do not know is, that when the first examination on the biopsy has been performed, the tissue is kept and stored at the histopathology department of the hospital, where the biopsy has been performed. This stored tissue material can be used for thorough (genetic) tissue analyses and in-depth sequencing. It is known that tumors show the accumulation of several genetic modifications, thus providing cancer cells with the selective growth advantage to initiate expansion. Now, sophisticated high-throughput technologies enable the identification of these mutated genes in cancers that can lead to a potent targeted therapy.
It is crucial to perform a thorough broad-spectrum screening so that every patient has a chance to explore all possibilities of a targeted treatment, may it be in a private setting or a clinical trial elsewhere. So it is most important to first find a laboratory that looks for all markers and mutations, and second, to find an oncologist who is willing to work with you in the best (and targeted) way possible.
Step 1 : Contact us
Important: Our oncological team is happy to talk to you by phone to get a deeper understanding about your specific case, enabling to provide you with a provisional treatment plan and cost estimate. Our oncologists will provide you all the details on medications, therapeutics and treatments including underlying mechanism and side effects. After a physical examination and an in-depth discussion with you on-site, the definite treatment plan will be discussed. Please understand that complex medical processes as mentioned above can only be explained through a thorough consultation on-site.