Updates in Cancer Therapy

Great advances in cancer treatments have been made over the last years, especially in the emerging field of cancer immunotherapy. Have a look at the selection of scientific publications, providing an insight about how important clinical research truly is, or visit our Facebook page for more information:

18. March 2020

Updated Results of PURE-01 with Preliminary Activity of Neoadjuvant Pembrolizumab in Patients with Muscle-invasive Bladder Carcinoma with Variant Histologies.

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17. March 2020

SUNSHINE Trial: High-Dose Vitamin D May Benefit Patients With Metastatic Colorectal Cancer

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16. March 2020

Antibody–drug conjugate, GSK2857916, in relapsed/refractory multiple myeloma: an update on safety and efficacy from dose expansion phase I study

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13. March 2020

Durvalumab plus platinum–etoposide versus platinum–etoposide in first-line treatment of extensive-stage small-cell lung cancer (CASPIAN): a randomised, controlled, open-label, phase 3 trial

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11. March 2020

Mosunetuzumab Induces Complete Remissions in Poor Prognosis Non-Hodgkin Lymphoma Patients, Including Those Who Are Resistant to or Relapsing After Chimeric Antigen Receptor T-Cell (CAR-T) Therapies, and Is Active in Treatment through Multiple Lines

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10. March 2020

Analysis of 4-Year Survival With Nivolumab in Patients Previously Treated for Advanced NSCLC

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06. March 2020

ESMO 2019: PROfound: Phase 3 Study of Olaparib vs. Enzalutamide or Abiraterone for Metastatic Castration-Resistant Prostate Cancer with Homologous Recombination Repair Gene Alterations

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06. March 2020

TOPARP-B: A phase II randomized trial of the poly(ADP)-ribose polymerase (PARP) inhibitor olaparib for metastatic castration resistant prostate cancers (mCRPC) with DNA damage repair (DDR) alterations

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05. March 2020

Pharmacologic management of cognitive impairment induced by cancer therapy

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04. March 2020

Effect of Neoadjuvant Chemotherapy Plus Regional Hyperthermia on Long-term Outcomes Among Patients With Localized High-Risk Soft Tissue Sarcoma: The EORTC 62961-ESHO 95 Randomized Clinical Trial.

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03. March 2020

Sequential Versus Combination Therapy of Metastatic Colorectal Cancer Using Fluoropyrimidines, Irinotecan, and Bevacizumab: A Randomized, Controlled Study-XELAVIRI (AIO KRK0110).

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28. February 2020

Neutrophil-to-lymphocyte ratio evolution is an independent predictor of early progression of second-line nivolumab-treated patients with advanced non-small-cell lung cancers

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26. February 2020

Tumor Mutation Burden—From Doubts to Concerns—In Reply

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19. February 2020

Actively personalized vaccination trial for newly diagnosed glioblastoma

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19. February 2020

A defined commensal consortium elicits CD8 T cells and anti-cancer immunity

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18. February 2020

The fungal mycobiome promotes pancreatic oncogenesis via activation of MBL

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17. February 2020

Old drugs bring new hope to a cancer that lacks precision therapy

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17. February 2020

Hepatocytes direct the formation of a pro-metastatic niche in the liverHepatocytes direct the formation of a pro-metastatic niche in the liver

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13. February 2020

Effect of Metformin Plus Tyrosine Kinase Inhibitors Compared With Tyrosine Kinase Inhibitors Alone in Patients With Epidermal Growth Factor Receptor–Mutated Lung Adenocarcinoma

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12. February 2020

Assessment of Molecular Relapse Detection in Early-Stage Breast Cancer.

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11. February 2020

A systems mechanism for KRAS mutant allele–specific responses to targeted therapy

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31. January 2020

Neoadjuvant Pembrolizumab Combo Prolongs pCR in Phase III TNBC Study

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31. January 2020

ESMO Immuno-Oncology 2018: Does Proton Pump Inhibitor Therapy Impact the Efficacy of Nivolumab Plus Ipilimumab?

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29. January 2020

FDA Accepts Sacituzumab Govitecan Application for TNBC

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28. January 2020

FDA approves fam-trastuzumab deruxtecan-nxki for unresectable or metastatic HER2-positive breast cancer

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16. December 2019

Tucatinib, Trastuzumab, and Capecitabine for HER2-Positive Metastatic Breast Cancer

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11. December 2019

Hair dye and chemical straightener use and breast cancer risk in a large US population of black and white women

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25. November 2019

Pembrolizumab alone or with chemotherapy versus cetuximab with chemotherapy for recurrent or metastatic squamous cell carcinoma of the head and neck (KEYNOTE-048): a randomised, open-label, phase 3 study

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20. November 2019

Results of a Multicenter Phase II Study of Atezolizumab and Bevacizumab for Patients With Metastatic Renal Cell Carcinoma With Variant Histology and/or Sarcomatoid Features

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17. November 2019

Nivolumab Plus Bevacizumab in Relapsed Ovarian Cancer

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27. October 2019

First Patients Dosed in Phase 1/2 Trial Testing Galinpepimut-S, Keytruda Combo in Advanced Cancers

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17. October 2019

ESMO 2019: Veliparib Plus First-Line Chemotherapy and as Maintenance Therapy in High-Grade Serous Ovarian Cancer

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27. September 2019

Safety and Efficacy of Nivolumab Monotherapy in Recurrent or Metastatic Cervical, Vaginal, or Vulvar Carcinoma: Results From the Phase I/II CheckMate 358 Trial

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21. September 2019

Enzalutamide with Standard First-Line Therapy in Metastatic Prostate Cancer

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20. August 2019

Regular Aspirin Use and Risk of Hepatocellular Carcinoma and Epithelial Ovarian Cancer

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06. August 2019

Do TP53 and ESR2 Interactions Change Prognosis in Triple-Negative Breast Cancer?

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04. August 2019

Metastatic triple-negative breast cancer patient with TP53 tumor mutation experienced 11 months progression-free survival on bortezomib monotherapy without adverse events after ending standard treatments with grade 3 adverse events

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28. July 2019

Ramucirumab plus pembrolizumab in patients with previously treated advanced non-small-cell lung cancer, gastro-oesophageal cancer, or urothelial carcinomas (JVDF): a multicohort, non-randomised, open-label, phase 1a/b trial

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17. June 2019

FDA Approves Pembrolizumab for the First-Line Treatment of Head and Neck Squamous Cell Carcinoma

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24. May 2019

SABCS 2018: KATHERINE Trial: Adjuvant Ado-Trastuzumab Emtansine vs Trastuzumab in Early-Stage HER2-Positive Breast Cancer

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13. May 2019

Avelumab plus Axitinib versus Sunitinib for Advanced Renal-Cell Carcinoma

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08. May 2019

Personalized Cancer Treatment

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02. May 2019

Ramucirumab after sorafenib in patients with advanced hepatocellular carcinoma and increased α-fetoprotein concentrations (REACH-2): a randomised, double-blind, placebo-controlled, phase 3 trial

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17. April 2019

Cancer: 'Off-the-shelf' stem cell treatment enters clinical trial

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12. April 2019

Vaccine Plus Trastuzumab in Preventing Recurrence of HER2–Low-Expressing Breast Cancer

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29. March 2019

Pertuzumab plus trastuzumab for HER2-amplified metastatic colorectal cancer (MyPathway): an updated report from a multicentre, open-label, phase 2a, multiple basket study

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29. March 2019

Pertuzumab plus trastuzumab for HER2-amplified metastatic colorectal cancer (MyPathway): an updated report from a multicentre, open-label, phase 2a, multiple basket study

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20. March 2019

TBCRC 022: A Phase II Trial of Neratinib and Capecitabine for Patients With Human Epidermal Growth Factor Receptor 2–Positive Breast Cancer and Brain Metastases

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14. March 2019

Cabozantinib in Patients with Advanced and Progressing Hepatocellular Carcinoma.

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08. March 2019

Neoadjuvant anti-PD-1 immunotherapy promotes a survival benefit with intratumoral and systemic immune responses in recurrent glioblastoma

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28. February 2019

Pembrolizumab plus Axitinib versus Sunitinib for Advanced Renal-Cell Carcinoma.

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22. February 2019

Neoadjuvant anti-PD-1 immunotherapy promotes a survival benefit with intratumoral and systemic immune responses in recurrent glioblastoma.

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12. February 2019

Lorlatinib Shows Overall and Intracranial Activity in ALK-Positive NSCLC

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31. January 2019

PACIFIC Trial of Durvalumab Sets Standard in Stage III Unresectable NSCLC

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27. January 2019

Atezolizumab and Nab-Paclitaxel in Advanced Triple-Negative Breast Cancer

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22. January 2019

Exercise as part of cancer treatment

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12. December 2018

SABCS 2018: SOLAR-1: Liquid Biopsies in Predicting Benefit of Alpelisib in PIK3CA-Mutant Breast Cancer

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30. November 2018

ELOQUENT-3: Addition of Elotuzumab to Pomalidomide and Dexamethasone in Previously Treated Multiple Myeloma

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24. November 2018

Obesity-induced Immune Dysfunction and its Consequences in Cancer

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15. November 2018

The Mediterranean Diet Reduces the Risk and Mortality of the Prostate Cancer: A Narrative Review

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11. November 2018

Exercise Therapy for Symptom Management and Treatment in Patients With Cancer

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08. November 2018

Durvalumab Improves Overall Survival in Unresectable Stage III NSCLC

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27. October 2018

Association of Analgesic Use With Risk of Ovarian Cancer in the Nurses’ Health Studies

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15. October 2018

Nivolumab and Ipilimumab Effective against Melanoma. That Has Spread to the Brain.

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09. October 2018

The Association Between Dietary Quality and Overall and Cancer-Specific Mortality Among Cancer Survivors, NHANES III

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09. October 2018

A Menu for Cancer Risk Reduction? Five truths about the role of food and diet in cancer prevention

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14. August 2018

Abemaciclib/Pembrolizumab Combo Shows Early Promise for HR+/HER2- Breast Cancer

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19. July 2018

What is 'checkpoint therapy' and why did it win the medicine Nobel prize?

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19. July 2018

What is 'checkpoint therapy' and why did it win the medicine Nobel prize?

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15. July 2018

IMpassion130: Atezolizumab Plus Nab-Paclitaxel in Metastatic or Locally Advanced Triple-Negative Breast Cancer

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11. June 2018

Immune recognition of somatic mutations leading to complete durable regression in metastatic breast cancer.

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11. June 2018

Immune-System Therapy Eradicated Breast Cancer in New Breakthrough

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11. May 2018

Immunotherapy and radiation in glioblastoma.

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01. April 2018

Prognostic significance of marital status in breast cancer survival: A population-based study.

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23. March 2018

Timing of Aspirin and Other Nonsteroidal Anti-Inflammatory Drug Use Among Patients With Colorectal Cancer in Relation to Tumor Markers and Survival.

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28. February 2018

Cancer vaccines in colon and rectal cancer over the last decade: lessons learned and future directions.

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05. February 2018

Physician age and outcomes in elderly patients in hospital in the US: observational study

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30. January 2018

Proof-of-Principle Study of Combination Checkpoint Inhibitor Plus Trastuzumab in HER2-Positive Advanced Breast Cancer

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26. January 2018

Tumor Mutational Burden as an Independent Predictor of Response to Immunotherapy in Diverse Cancers

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20. January 2018

Preventive Effects of Cocoa and Cocoa Antioxidants in Colon Cancer

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20. January 2018

American Cancer Society (ACS) Nutrition and Physical Activity Guidelines after colon cancer diagnosis and disease-free (DFS), recurrence-free (RFS), and overall survival (OS) in CALGB 89803 (Alliance)

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18. January 2018

Pembrolizumab as first-line therapy for metastatic non-small-cell lung cancer

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15. January 2018

FDA Grants DS-8201 Breakthrough Designation for HER2+ Breast Cancer

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28. October 2017

Clinical decision-making for immunotherapy in metastatic renal cell carcinoma

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22. October 2017

Osimertinib Granted Breakthrough Therapy Designation for First-Line Treatment of EGFR Mutation–Positive NSCLC

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19. October 2017

Cancers Associated With Overweight and Obesity Make Up 40% of Cancers Diagnosed in the United States

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25. September 2017

FDA Approves Daratumumab in Combination With Pomalidomide and Dexamethasone for Relapsed or Refractory Multiple Myeloma

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19. September 2017

The EGFR variant III mutant as a target for immunotherapy of glioblastoma multiforme

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06. September 2017

Efficacy and Safety of Anti-Trop-2 Antibody Drug Conjugate Sacituzumab Govitecan (IMMU-132) in Heavily Pretreated Patients With Metastatic Triple-Negative Breast Cancer

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05. September 2017

FDA Approves Panitumumab for Use in Wild-Type RAS Metastatic Colorectal Cancer

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20. July 2017

Angiosarcoma treated successfully with anti-PD-1 therapy - a case report

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12. June 2017

Genentech: Beyond The Cycle

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10. June 2017

Cancer Drug Proves to Be Effective Against Multiple Tumors

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08. June 2017

Immunotherapy Combination Shows Promise in Early Stage Triple Negative Breast Cancer

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06. June 2017

ASCO 2017: Chance of Colon Cancer Recurrence Nearly Cut in Half in Patients Who Consume Nuts

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03. June 2017

Checkpoint Inhibitors Advancing in Multiple GI Cancers

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31. May 2017

Duke researchers develop treatment that triples survival time of brain cancer patients

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31. May 2017

Long-term complete remission with Ipilimumab in metastatic castrate-resistant prostate cancer: case report of two patients

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13. May 2017

Personalized peptide vaccine-induced immune response associated with long-term survival of a metastatic cholangiocarcinoma patient

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13. May 2017

Personalized peptide vaccine-induced immune response associated with long-term survival of a metastatic cholangiocarcinoma patient

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17. April 2017

Brain Trust: Cutting-Edge Treatments for Glioblastoma on the Rise

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16. April 2017

Nanoliposomal irinotecan with fluorouracil and folinic acid in metastatic pancreatic cancer after previous gemcitabine-based therapy (NAPOLI-1): a global, randomised, open-label, phase 3 trial

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02. April 2017

Nivolumab in renal cell carcinoma: latest evidence and clinical potential

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12. March 2017

Predictive biomarkers for the efficacy of peptide vaccine treatment: based on the results of a phase II study on advanced pancreatic cancer

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08. March 2017

Immunological Effects of Conventional Chemotherapy and Targeted Anticancer Agents

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07. March 2017

Ovarian cancer and the immune system — The role of targeted therapies

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21. February 2017

Nivolumab in patients with DNA mismatch repair deficient/microsatellite instability high metastatic colorectal cancer: Update from CheckMate 142

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08. February 2017

Rucaparib in relapsed, platinum-sensitive high-grade ovarian carcinoma: an international, multicentre, open-label, phase 2 trial.

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05. February 2017

Olaratumab and doxorubicin versus doxorubicin alone for treatment of soft-tissue sarcoma: an open-label phase 1b and randomised phase 2 trial

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16. November 2016

Systemic effect of catumaxomab in a patient with metastasized colorectal cancer: a case report

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13. November 2016

Immunotherapy moves to the front lines in fight against lung cancer

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09. November 2016

Impressive Early Data for Rovalpituzumab Tesirine in Small Cell Lung Cancer

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24. October 2016

Pembrolizumab versus Chemotherapy for PD-L1-Positive Non-Small-Cell Lung Cancer

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12. October 2016

The Science Behind Guided Imagery

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16. September 2016

Complete remission in a patient with recurrent acute myeloid leukemia induced by vaccination with WT1 peptide in the absence of hematological or renal toxicity

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27. August 2016

The development and use of the E75 (HER2 369-377) peptide vaccine

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27. August 2016

Evaluation of the HER2/neu-derived peptide GP2 for use in a peptide-based breast cancer vaccine trial

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18. August 2016

Personalized peptide vaccine-induced immune response associated with long-term survival of a metastatic cholangiocarcinoma patient

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01. August 2016

Harnessing the immune system to fight cancer

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13. July 2016

Association of WT1 IgG antibody against WT1 peptide with prolonged survival in glioblastoma multiforme patients vaccinated with WT1 peptide

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26. April 2016

Neoadjuvant T-DM1/Pertuzumab Combo Boosts pCR in HER2+ Breast Cancer

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14. April 2016

Phase I clinical trial of a five-peptide cancer vaccine combined with cyclophosphamide in advanced solid tumors

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14. April 2016

Triple peptide vaccination as consolidation treatment in women affected by ovarian and breast cancer: Clinical and immunological data of a phase I/II clinical trial

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10. March 2016

Peptide vaccines in breast cancer: The immunological basis for clinical response

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25. February 2016

Triple peptide vaccination as consolidation treatment in women affected by ovarian and breast cancer: Clinical and immunological data of a phase I/II clinical trial

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23. January 2016

With Immunotherapy, Glimmers of Progress against Glioblastoma

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15. January 2016

Complete remission of liver metastasis of pancreatic cancer under vaccination with a HLA-A2 restricted peptide derived from the universal tumor antigen survivin

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22. November 2015

Short Peptide Vaccine Induces CD4+ T Helper Cells in Patients with Different Solid Cancers

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22. November 2015

Adjuvant HER2/neu peptide cancer vaccines in breast cancer

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09. October 2015

Immunological responses in a patient with glioblastoma multiforme treated with sequential courses of temozolomide and immunotherapy: Case study

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08. October 2015

Immune modulation for cancer therapy

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02. October 2015

Case report: A breast cancer patient treated with GcMAF, sonodynamic therapy and hormone therapy

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02. October 2015

Immunotherapy of metastatic colorectal cancer with vitamin D-binding protein-derived macrophage-activating factor, GcMAF.

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30. September 2015

Cancer immunotherapy with peptide-based vaccines: What have we achieved? Where are we going?

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News

17. March 2020

We would like to share with you a comment in regard to the corona virus pandemia.

29. January 2020

January 2020 - Up2Date in HER2-positive breast cancer: New therapy strategy available

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